Yes, and I think it's very possible there might be only 5 copies ever printed.
Certainly if you're reasonably successful you'll get it purchased by libraries-- so you can head toward 100 copies. But somehow that just doesn't seem like much.
This applies especially to older, print-only materials. Open access online materials are quite different (if perhaps less profitable).
I'm thinking mostly about those books that have 2-3 listings on worldcat.org and are "out of stock" on Amazon. I had a book sent by inter-library loan from Sweden (it was a copy personally donated by the author), for all I know the only copy in the world (yet cited a few times), and another that I eventually got scans of from the University of Hawaii, which I'm pretty sure was one of three copies in the world (the others in Indonesia and Papua New Guinea [where it was 'published']).